A research spearheaded by researchers at Penn Medicine discovered that childhood trauma is connected to abnormal connectivity in the adults’ brain with MDD (major depressive disorder). The document, posted in PNAS (Proceedings of the National Academy of Sciences), is the first data-supported research to display system-level, symptom-particular modifications in MDD in brain network connectivity.
“With predictions of almost 10% of all kids in the US having been considered for child abuse, the implication of child mistreatment on brain function and development is an essential contemplation,” claimed McLure professor of Radiology, Psychiatry, and Neurology, Yvette I. Sheline, to the media. Sheline is also the director at the Perelman School of Medicine for the CNDS (Center for Neuromodulation in Depression and Stress) at the University of Pennsylvania. “This research not only verifies the significant relationship between major depression and childhood trauma, but also connects experiences of childhood trauma for patients with particular abnormalities in operational brain network. This recommends a potential environmental contributor to neurobiological signs.”
On a related note, a drug employed to cure bipolar disorder and other types of depression might assist to prevent nerve cells from dying and conserve brain function in patients suffering from a traumatic brain injury, as per a new study by Rutgers University.
In study posted in Scientific Reports, Rutgers researchers found that lithium and rapamycin defended nerve cells in the brain and prevented the chemical glutamate from conveying signals to different cells and making further damage to the brain cell.
“Many medicines now employed for those suffering with traumatic brain injury aim on curing the signs and preventing the pain rather than of defending any further injury from taking place,” claimed Bonnie Firestein, lead author and professor in the School of Arts and Sciences for the Department of Neuroscience and Cell Biology at Rutgers University-New Brunswick.