Neuronostatin To Prevent Hypoglycemia In Diabetes Type 1 And 2 Patients On Insulin

Patients who suffer from either type 1 or type 2 diabetes and practically live their lives depended on insulin have severely high risk of having hypoglycemia or commonly known as low blood sugar. Recently, a study has come up with an observation that a specific protein functioning inside the pancreas might provide ways of new treatment which would protect a patient against this life-threatening disease.

The protein has been discovered by an assistant professor in the department of pharmacology and physiology from Saint Louis University, Dr. Gina L.C. Yosten and her team. The name of the protein is neuronostatin. The team discovered that neuronostatin is helpful in preventing hypoglycemia by increasing the blood sugar level in the pancreas in two possible ways. The first one is by forming lesser amount of insulin that helps in decreasing the level of blood sugar. The second way is by producing more amount of glucagon, which is a hormone that helps in increasing blood sugar.

In a latest research, rats were injected with neuronostatin and soon their blood sugar levels got increased. In Type 1 diabetes, the body is unable to make ample amount of insulin, therefore they require insulin on a regular basis to stop the level of blood sugar to rise to life-threatening levels. In Type 2 diabetes, although the body forms insulin, yet the system is unable to use it properly. When the level of insulin increases in the body due to regular injection, patients are prone to feel sleepy or dizzy. In the study conducted by Dr. Yosten and her team, it was proved how neuronostatin helped in increasing glucagon by forming interaction with specific kinds of receptor proteins inside alpha cells of the pancreas that then release the hormone. Neuronostatin also helps in decreasing the production of insulin through making use of beta cells in the pancreas.

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